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An Exceedingly Mild, Green Synthesis of Substituted N ‐3‐diaryl‐1,8‐naphthyridin‐2‐amine Derivatives and Their Antimicrobial Activity
Author(s) -
Ravi Dharavath,
Rambabu Sirgamalla,
Ashok Kommakula,
Madhu Palithapu,
Sakram Boda
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3125
Subject(s) - chemistry , antimicrobial , amine gas treating , reaction conditions , aryl , solvent , combinatorial chemistry , organic chemistry , catalysis , alkyl
An exceedingly and highly efficient procedure has been described for the synthesis of substituted N ‐3‐diaryl‐1,8‐naphthyridin‐2‐amines by the reaction of 2‐chloro‐3‐aryl‐1,8‐naphthyridines with various anilines in the presence of N ‐methyl‐2‐pyrrolidone and K 2 CO 3 under thermal green solvent‐free conditions. The significant features of this green reaction include very good yields in purity, simple experimental, short reaction time, easy workability, and avoidance of toxic solvents. All synthesized compounds have been evaluated for their antibacterial activity.