Selective Synthesis of 3‐(α,α‐Dibromoacetyl)‐4‐hydroxy‐6‐methyl‐2 H ‐pyran‐2‐one as an Excellent Precursor for the Synthesis of 2‐Substituted 4‐(4‐Hydroxy‐6‐methyl‐2 H ‐2‐oxopyran‐3‐yl)thiazoles as Antimicrobial and Antifungal Agents | Zendy

Kapoor Jitander K. | Zendy; Prakash Richa | Zendy; Kumar Ajay | Zendy; Saini Deepika | Zendy; Arora Loveena | Zendy

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Selective Synthesis of 3‐(α,α‐Dibromoacetyl)‐4‐hydroxy‐6‐methyl‐2 H ‐pyran‐2‐one as an Excellent Precursor for the Synthesis of 2‐Substituted 4‐(4‐Hydroxy‐6‐methyl‐2 H ‐2‐oxopyran‐3‐yl)thiazoles as Antimicrobial and Antifungal Agents

Author(s) -

Kapoor Jitander K.,

Prakash Richa,

Kumar Ajay,

Saini Deepika,

Arora Loveena

Publication year - 2018

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3116

Subject(s) - chemistry , pyran , halogenation , antifungal , antimicrobial , stereochemistry , organic chemistry , medicine , dermatology

A selective synthesis of 3‐(α,α‐dibromoacetyl)‐4‐hydroxy‐6‐methyl‐2 H ‐pyran‐2‐one ( 3 ) has been achieved by bromination of DHA using CuBr 2 /CHCl 3 ‐EtOAc. The reaction of 3 with different thioureas/thiomides/thiosemicarbazide offers a convenient and efficient method for the syntheses of 2‐substituted 4‐(4‐hydroxy‐6‐methyl‐2 H ‐2‐oxopyran‐3‐yl)thiazoles. These thiazoles were evaluated for their antimicrobial and antifungal activity.

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