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The Influence of Condensed Cycle on Regiochemistry of Electrophilic Heterocyclization of 3‐Alkenyl‐2‐Thioxopyrimidin‐4‐One by p ‐Alkoxyphenyltellurium Trichloride
Author(s) -
Kut Mykola,
Onysko Mikhajlo,
Lendel Vasil
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3114
Subject(s) - chemistry , regioselectivity , electrophile , medicinal chemistry , annulation , electrophilic substitution , organic chemistry , catalysis
Electrophilic heterocyclization of 5‐alkenyl‐1‐methyl‐6‐thioxopyrazolo[3,4‐ d ]pyrimidin‐4‐ones and 3‐alkenyl‐2‐thioxoquinazoline‐4‐ones under the action of p ‐alkoxyphenyltellurium trichloride leads to annulation of thiazoline cycle with formation of 7‐[( p ‐alkoxyphenyl)telluromethyl]‐1‐methyl‐6,7‐dihydropyrazolo[3,4‐ d ][1,3]thiazolo[3,2‐ a ]pyrimidin‐4(1 H )‐ones hydrochlorides and 2‐( p ‐alkoxyphenyl)dichlorotelluromethyl‐2,3‐dihydro ‐ 5 H ‐[1,3]thiazolo[2,3‐ b ]quinazolin‐5‐ones hydrochlorides. Reduction of salts by the action of excess of sodium sulfite leads to formation of arylhetaryl telluride.

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