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An Efficient Synthesis of 1′,7′,8′,9′‐Tetrahydrospiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]quinoline]‐2,5′(6′ H )‐dione Derivatives in Aqueous Medium
Author(s) -
Zhu Guangzhou,
Gao Lingli,
Yu Qiuyu,
Qin Yaqi,
Xi Junhua,
Rong Liangce
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3111
Subject(s) - chemistry , indoline , quinoline , aqueous medium , amine gas treating , substrate (aquarium) , aqueous solution , carbon 13 nmr , pyrazolones , proton nmr , organic chemistry , medicinal chemistry , combinatorial chemistry , oceanography , geology
An efficient and green reactions of isatins, 3‐amine‐1 H ‐pyrazole (5‐methyl‐1 H ‐pyrazol‐3‐amine) and 1,3‐diketone in aqueous medium for the synthesis of novel 1′,7′,8′,9′‐tetrahydrospiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]quinoline]‐2,5′(6′ H )‐dione derivatives were reported in this research. The advantages of this reaction are simple operation, mild‐reaction conditions, wide scope substrate, high yields, and friendly environment. The products were confirmed by IR, 1 H NMR, 13 C NMR, and HRMS.