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Efficient Domino Strategy for the Synthesis of Substituted Bipyrazole Derivatives
Author(s) -
Zhang Xi,
Long Kai,
He Jiayi,
Fu Jialian,
Zhang Furen,
Li Chunmei
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3096
Subject(s) - chemistry , domino , catalysis , cascade reaction , combinatorial chemistry , reaction conditions , domino effect , organic chemistry , physics , nuclear physics
An efficient domino strategy for the synthesis of bipyrazole derivatives has been established successfully using Y(OTf) 3 as catalyst. This new reaction allows direct formation of highly functionalized bipyrazole derivatives with a wide diversity in substituents in a one‐pot manner. The present synthesis shows attractive characteristics, such as the use of water as reaction media, simple one‐pot operation, highly efficient catalyst, and mild reaction conditions.