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1 H ‐1,2,3‐Triazole‐tethered Isatin–coumarin Hybrids: Design, Synthesis and In Vitro Anti‐mycobacterial Evaluation
Author(s) -
Liu Bi,
Hu Guowen,
Tang Xiuqin,
Wang Guangqiang,
Xu Zhi
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3093
Subject(s) - isatin , coumarin , chemistry , mycobacterium smegmatis , in vitro , triazole , cytotoxicity , 1,2,3 triazole , stereochemistry , oxadiazole , mycobacterium tuberculosis , combinatorial chemistry , vero cell , biochemistry , tuberculosis , organic chemistry , medicine , pathology
A series of novel 1 H ‐1,2,3‐triazole‐tethered isatin–coumarin hybrids 7a – l integrate three anti‐tuberculosis bioactive substances/pharmacophoric units including coumarin, isatin, and I ‐ A09 were designed, synthesized, and tested for their in vitro anti‐mycobacterial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis H37Rv as well as cytotoxicity in VERO cell line. The results showed that all hybrids exhibited weak to moderate activity against the tested two strains with minimum inhibitory concentration ranging from 50 to 200 μg/mL.