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Synthesis and Antioxidant Evaluation of Quinoxalino[2′,3′:5,6][1,3,4]thiadiazino[2,3‐ b ]quinazolin‐15‐ones: Derivatives of a Novel Ring System
Author(s) -
Mousavi Mahsa,
Bakavoli Mehdi,
Shiri Ali,
Eshghi Hossein
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3078
Subject(s) - chemistry , derivatization , ring (chemistry) , antioxidant , alkyl , condensation , condensation reaction , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry , high performance liquid chromatography , catalysis , physics , thermodynamics
Quinoxalino[2′,3′:5,6][1,3,4]thiadiazino[2,3‐ b ]quinazolin‐15‐one, a novel fused heterocyclic system, was synthesized from a one‐pot condensation reaction of 2,3‐dichloroquinoxaline and 3‐amino‐2‐thioxo‐2,3‐dihydroquinazolin‐4(1 H )‐one under mild condition. Derivatization was performed on treatment of the titled compound with several alkyl bromides. In vitro antioxidant activity of the synthesized compounds was evaluated.