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Microwave Assisted Green Synthesis of Pyrazole, 1, 2, 3‐ Triazole Based Novel Benzohydrazones and Their Antibacterial Activities
Author(s) -
K Sravanthi,
P Snehalatha,
Subhashini NJP
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3073
Subject(s) - chemistry , bacillus cereus , antibacterial activity , pyrazole , bacteria , gram , escherichia coli , staphylococcus aureus , acetic acid , 1,2,4 triazole , pseudomonas aeruginosa , gram negative bacteria , cereus , combinatorial chemistry , organic chemistry , biochemistry , genetics , gene , biology
A series of novel pyrazole, triazole based benzohydrazones ( 7a‐l ) were synthesized via conventional and microwave methods in the presence of acetic acid catalyst. Microwave method provided green and economical approach towards the synthesis of novel Schiff bases ( 7a‐l ). Some intermediates and all the final compounds were characterized by NMR, mass, and elemental analysis. The compounds were screened for their in vitro antibacterial activity against Gram‐negative bacteria ( Escherichia coli and Pseudomonas aeruginosa ) and Gram‐positive bacteria ( Staphylococcus aureus and Bacillus cereus ). Compounds 7e and 7g showed good antibacterial activity.