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Novel bis(dihydropyrano[3,2‐ c ]chromenes): Synthesis, Antiproliferative Effect and Molecular Docking Simulation
Author(s) -
Abdella Amna M.,
Mohamed Magda F.,
Mohamed Aly F.,
Elwahy Ahmed H. M.,
Abdelhamid Ismail A.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3072
Subject(s) - chemistry , malononitrile , docking (animal) , pyridine , protein data bank (rcsb pdb) , stereochemistry , combinatorial chemistry , hydrazone , acetic acid , organic chemistry , catalysis , medicine , nursing
An efficient and convenient route for the synthesis of novel bis dihydropyrano[3,2‐ c ]chromenes is reported. The synthetic pathway involves one‐pot, multicomponent reaction of bis‐aldehydes, malononitrile, and 4‐hydroxycoumarin in the presence of pyridine or acetic acid/sodium acetate. A stepwise approach for the synthesis of the target compounds was also investigated. The anticancer activity of the synthesized products against MCF7, HEPG2, and A549 cell lines was assessed. Attempts to detect the molecular action of 6g, docking simulation was done using DHFR PDB:ID (1DLS). The study revealed that compound 6g was strongly fit into the active sites of the target protein through six bindings, and hence, it was considered as promising inhibitor for cancer proliferation.