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Survey Reactivity of Some Substituted Quinazolinones with Pentafluoro(chloro)pyridine
Author(s) -
RanjbarKarimi Reza,
Davodian Tayebeh,
Mehrabi Hossein
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3067
Subject(s) - chemistry , quinazolinone , pyridine , reactivity (psychology) , nucleophile , ring (chemistry) , nucleophilic substitution , nuclear magnetic resonance spectroscopy , medicinal chemistry , carbon 13 nmr , organic chemistry , stereochemistry , catalysis , medicine , alternative medicine , pathology
A new series of 4‐hetroaryl substituted quinazolines were designed and synthesized by the reaction of pentafluoro(chloro)pyridine and 2‐substituted quinazolinone. The aromatic nucleophilic substitution of pentafluoro(chloro)pyridine with quinazolinone occurs at the 4‐position of pyridine ring by the oxygen site (O‐centered nucleophile) of quinazolinone. The structures of all the compounds were confirmed by IR, 1 H NMR, 19 F NMR, and 13 C NMR spectroscopy as well as elemental analysis.