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[Emim][BF 4 ]: An Efficient Green Protocol for the Synthesis of Bioactive 2‐(5‐(substituted)‐2,6‐dioxo‐1,2,5,6‐tetrahydropyrimidin‐4‐yl)‐2,3‐dihydrophthalazine‐1,4‐dione Derivatives
Author(s) -
Sumalatha Jorepalli,
Radha Rani Chinthaparthi,
Sreedevi Adikay
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3066
Subject(s) - chemistry , ionic liquid , barbituric acid , cancer cell lines , condensation , combinatorial chemistry , condensation reaction , organic chemistry , stereochemistry , cancer cell , catalysis , cancer , medicine , physics , thermodynamics
The present study is designed to synthesize the 2‐(5‐(substituted)‐2,6‐dioxo‐1,2,5,6‐tetrahydropyrimidin‐4‐yl)‐2,3‐dihydrophthalazine‐1,4‐diones and investigate their anticancer activity. This is the first example of the condensation reaction of a series of phthalhydrazide derivatives in ionic liquid. In this investigation, the titled compounds syntheses were carried out by simple and efficient three component coupling of phthalhydrazide, aldehydes, and barbituric acid in the presence of [Emim][BF 4 ] ionic liquid. This methodology was provided and promotes the higher product yields in shorter reaction times and mild reaction conditions. The title compounds were tested for their anticancer activity. Some of them were shown the significant cytotoxic activity against the selected cancer cell lines.