Premium
Synthesis and Hypolipidemic Activity of New 6,6‐Disubstituted 3‐R‐6,7‐Dihydro‐2 H ‐[1,2,4]triazino[2,3‐ c ]quinazolin‐2‐Ones
Author(s) -
Voskoboynik Оleksii Yu.,
Kolomoets Oleksandra S.,
Antypenko Oleksii M.,
Zhernova Galina О.,
Nosulenko Inna S.,
Berest Galyna G.,
Shvets Volodymyr M.,
Kovalenko Sergiy I.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3054
Subject(s) - chemistry , acetic acid , tricyclic , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry
Presented article describes the synthesis and hypolipidemic activity of previously unknown 6,6‐disubstituted 3‐R‐6,7‐dihydro‐2 H ‐[1,2,4]triazino[2,3‐ c ]quinazolin‐2‐ones. It was shown, that interaction of 6‐R‐3‐(2‐aminophenyl)‐1,2,4‐triazin‐5(2 Н )‐оnes with methylalkylketones in acetic acid resulted the single product, namely, the desired tricyclic derivatives. At the same time, after refluxing of 6‐R‐3‐(2‐aminophenyl)‐1,2,4‐triazin‐5(2 Н )‐оnes with methylarylketones in acetic acid the mixture of target compound and insignificant amount of corresponding 3‐substituted 6‐methyl‐2 H ‐[1,2,4]triazino[2,3‐ c ]quinazolin‐2‐ones were isolated. The mechanism of above‐mentioned mixture formation was discussed. The structures of all synthesized compounds were proven using the appropriate physicochemical methods. The compounds with promising lipid‐lowering activity were identified and the «structure — hypolipidemic activity» correlations were discussed.