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Synthesis of Some New Polyfunctionalized Pyridines
Author(s) -
Amer A. A
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3049
Subject(s) - chemistry , alkoxide , alkoxy group , pyridine , alcohol , sodium , medicinal chemistry , organic chemistry , catalysis , alkyl
5‐Methyl‐2,4‐dihydro‐3 H ‐pyrazol‐3‐one and/or 5‐methyl‐2‐phenyl‐2,4‐dihydro‐3 H ‐pyrazol‐3‐one was reacted with arylidenemalononitrile in the presence of sodium alkoxide to give 2‐amino‐6‐alkoxy‐4‐arylpyridine‐3,5‐dicarbonitrile 4a–e instead of the reported pyrazolo[3,4‐ b ]pyridine‐5‐carbonitriles. The same products 4a–e were prepared via reaction of arylidenemalononitrile with sodium alkoxide in an appropriative alcohol. However, the new synthetic route for preparation of their positional isomer 4‐amino‐6‐alkoxy‐2‐arylpyridine‐3,5‐dicarbonitrile 7a–j has been achieved via reaction of 2‐aminoprop‐1‐ene‐1,1,3‐tricarbonitrile with different aromatic aldehydes under the same conditions.