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Concise Synthesis and Pharmacological Applications of New α‐Lapachone Analogues
Author(s) -
Hamama Wafaa S.,
Hassanien Alaa E.,
Zoorob Hanafi H.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3047
Subject(s) - chemistry , lawsone , combinatorial chemistry , biological activity , stereochemistry , computational biology , biochemistry , organic chemistry , in vitro , biology
Synthesis of novel 1,4‐naphthoquinones structurally related to α‐lapachone skeleton and its annulated compounds were synthesized from lawsone (2‐hydroxynaphthalene‐1,4‐dione). Pharmacological studies provided indication of biological activities, including effects against hepatocellular carcinoma (HePG‐7) and mammary gland breast cancer (MCF‐7). The molecular structures of the target molecules were examined.