Premium
Functionalized Diphenyl‐Imidazolo‐Pyrimidines
Author(s) -
Lyubashov Pavel P.,
Povstyanoy Vyacheslav M.,
Krysko Andrey A.,
Plotkin Alexander,
Lovett Ilene,
Povstyaniy Mykhailo V.,
Lebedyeva Iryna O.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3044
Subject(s) - chemistry , imidazole , moiety , bromine , nucleophile , pyrimidine , reactivity (psychology) , amide , alkyl , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , catalysis , medicine , alternative medicine , pathology
Synthesis of novel imidazopyrimidines has been reported. These systems contain carbethoxy group at C5 of pyrimidine and bromine at C2 of imidazole. Reactivity of these two groups was studied, and the mobility of the carbethoxy group was confirmed by tracing the formation of the amide product and also with isolation of alkyl analogs while bromine did not react with N‐nucleophiles under various reaction conditions employed. New conjugates combine the properties of dihydropyrimidine and imidazole and therefore lead to the expansion of original properties of each heterocyclic moiety within the system.