Premium
Synthesis and Antibacterial Activity of Novel 1 H ‐indol‐2‐ol Derivatives
Author(s) -
Tu Hong,
Wu ShouQun,
Li XiaoQin,
Wan ZhenChao,
Wan JinLin,
Tian Kun,
Ouyang GuiPing
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3043
Subject(s) - ralstonia solanacearum , bacterial wilt , xanthomonas oryzae , chemistry , antibacterial activity , xanthomonas citri , bioassay , minimum inhibitory concentration , ralstonia , citrus canker , xanthomonas oryzae pv. oryzae , inoculation , microbiology and biotechnology , bacteria , in vitro , horticulture , organic chemistry , biochemistry , pathogen , biology , genetics , gene , enzyme
A series of novel 1 H ‐indol‐2‐ol derivatives were synthesized and evaluated their antibacterial activities against rice bacterial leaf blight, tobacco bacterial wilt, and citrus canker caused by Xanthomonas oryzae pv. oryzae ( Xoo ), Ralstonia solanacearum , and Xanthomonas axonopodis pv. citri via the turbidimeter test in vitro . Antibacterial bioassay indicated that most compounds demonstrated good inhibitory effect against Xoo and Ralstonia solanacearum . Especially, compound 4k demonstrated the best inhibitory effect against Xoo with half‐maximal effective concentration (EC 50 ) value of 8.27 μg/mL, which was even better than those of commercial agents Bismerthiazol and Thiodiazole copper.