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Design, Synthesis, Characterization, and Antimicrobial Evaluation of Novel 2‐(3, 5‐di methoxy‐4‐((1‐aryl‐ 1H ‐1, 2, 3‐triazole‐4‐yl) methoxy) phenyl) benzo[ d ]thiazoles
Author(s) -
N.J.P. Subhashini,
Chinthala Sravanthi,
Raj Shiva
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3033
Subject(s) - chemistry , thiophenol , propargyl bromide , antimicrobial , click chemistry , aryl , proton nmr , 1,2,3 triazole , carbon 13 nmr , bromide , propargyl , thiazole , triazole , combinatorial chemistry , organic chemistry , stereochemistry , medicinal chemistry , catalysis , alkyl
A series of 12 new 2‐(3, 5‐dimethoxy‐4‐((1‐Aryl‐4H‐1, 2, 3‐triazol‐4‐yl) methoxy) phenyl) benzo[ d ]thiazoles have been synthesized from the reaction of 4‐hydroxy‐3, 5‐dimethoxybenzaldehyde, o‐amino thiophenol, propargyl bromide, and different substituted aromatic azides using “click chemistry”. The structures of these compounds were established on the basis of Fourier Transform infrared, 1 H NMR, 13 C–NMR, and mass spectral analysis. Compounds ( 6a–l ) were screened for in vitro antimicrobial activity.