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Synthesis, Antifungal Activity, and SAR Study of Some New 6‐Perfluoropropanyl Quinoline Derivatives
Author(s) -
Fang YueMing,
Zhang RuiRui,
Shen ZhongHua,
Wu HongKe,
Tan ChengXia,
Weng JianQuan,
Xu TianMing,
Liu XingHai
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3031
Subject(s) - chemistry , quinoline , moiety , bioassay , pyricularia , antifungal , fungicide , positive control , stereochemistry , combinatorial chemistry , organic chemistry , microbiology and biotechnology , traditional medicine , botany , medicine , genetics , biology
A series of novel quinoline derivatives containing perfluoropropanyl moiety were designed and synthesized. The bioassay results showed that some of them exhibited good control efficacy against Pyricularia oryae. The fungicidal activity was affected by the substituted position in the molecule. It was found that the compound 3n possessed highest control effect against P. oryae at different concentration. It is better than that of control Tebufloquin.