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Synthesis of Polyfunctionalized Pyrroles via Green Chemical Methods
Author(s) -
Pagadala Ramakanth,
Anugu Sreenivasa
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3022
Subject(s) - chemistry , knoevenagel condensation , atom economy , catalysis , condensation reaction , elemental analysis , combinatorial chemistry , organic chemistry , proton nmr , solvent , carbon 13 nmr
Water was found to be an excellent solvent for the one‐pot synthesis of tetrasubstituted pyrrole derivatives under ultrasound involving the standard Knoevenagel condensation followed by the Michael type reaction. A new catalyst free system, excellent atom economy, ultrasound in water medium, short reaction times, good yields (88–93%), and ease of workup make this protocol more attractive and economically viable. The resulting substituted pyrroles are characterized by 1 H and 13 C NMR, elemental analysis, and mass spectral data.