Premium
Synthesis of New Pyrimido[4′,5′:3,4]pyrazolo[1,2‐ b ]phthalazine‐4,7,12‐triones: Derivatives of a New Heterocyclic Ring System
Author(s) -
Hosseininasab Nasrinsadat,
Davoodnia Abolghasem,
RostamiCharati Faramarz,
TavakoliHoseini Niloofar,
Khojastehnezhad Amir
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3019
Subject(s) - phthalazine , chemistry , ring (chemistry) , proton nmr , medicinal chemistry , organic chemistry , combinatorial chemistry
Several derivatives of the new pyrimido[4′,5′:3,4]pyrazolo[1,2‐ b ]phthalazine‐4,7,12‐trione ring system have been prepared by the reaction of 3‐amino‐1‐aryl‐5,10‐dioxo‐5,10‐dihydro‐1 H ‐pyrazolo[1,2‐ b ]phthalazine‐2‐carbonitriles with aliphatic carboxylic acids in the presence of phosphoryl chloride (POCl 3 ). The synthesized compounds were characterized on the basis of IR, 1 H NMR, and 13 C NMR spectral and microanalytical data.