Synthesis of New Pyrimido[4′,5′:3,4]pyrazolo[1,2‐ b ]phthalazine‐4,7,12‐triones: Derivatives of a New Heterocyclic Ring System | Zendy

Hosseininasab Nasrinsadat | Zendy; Davoodnia Abolghasem | Zendy; RostamiCharati Faramarz | Zendy; TavakoliHoseini Niloofar | Zendy; Khojastehnezhad Amir | Zendy

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Synthesis of New Pyrimido[4′,5′:3,4]pyrazolo[1,2‐ b ]phthalazine‐4,7,12‐triones: Derivatives of a New Heterocyclic Ring System

Author(s) -

Hosseininasab Nasrinsadat,

Davoodnia Abolghasem,

RostamiCharati Faramarz,

TavakoliHoseini Niloofar,

Khojastehnezhad Amir

Publication year - 2018

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3019

Subject(s) - phthalazine , chemistry , ring (chemistry) , proton nmr , medicinal chemistry , organic chemistry , combinatorial chemistry

Several derivatives of the new pyrimido[4′,5′:3,4]pyrazolo[1,2‐ b ]phthalazine‐4,7,12‐trione ring system have been prepared by the reaction of 3‐amino‐1‐aryl‐5,10‐dioxo‐5,10‐dihydro‐1 H ‐pyrazolo[1,2‐ b ]phthalazine‐2‐carbonitriles with aliphatic carboxylic acids in the presence of phosphoryl chloride (POCl 3 ). The synthesized compounds were characterized on the basis of IR, 1 H NMR, and 13 C NMR spectral and microanalytical data.

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