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P 2 O 5 Mediated an Efficient Synthesis and Biological Evaluation of Heterocyclic‐fused Pyrimidine Derivatives as an Antitubercular Agent
Author(s) -
Patil Kirti T.,
Warekar Poojali P.,
Patil Priyanka T.,
Undare Santosh S.,
Kolekar Govind B.,
Anbhule Prashant V.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3018
Subject(s) - chemistry , pyrimidine , barbituric acid , uracil , ethanol , condensation , biological activity , in vitro , combinatorial chemistry , mycobacterium tuberculosis , organic chemistry , stereochemistry , biochemistry , dna , tuberculosis , medicine , physics , pathology , thermodynamics
An efficient P 2 O 5 mediated protocol for the synthesis of pyrido[2,3‐d:6,5‐d]dipyrimidines has been developed through one‐pot three‐component condensation of aromatic aldehydes, barbituric acid/thiobarbituric acid, and 1,3‐dimethyl‐6‐amino‐uracil in ethanol. All the synthesized products were screened for their in vitro antitubercular activity, and results reveal that most of the compounds exhibited moderate to good activity against Mycobacterium tuberculosis H 37 R V strain.