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Synthesis and Antimicrobial Activity of Some New 3,4‐Disubstituted Pyrroles and Pyrazoles
Author(s) -
Simha Pulla Reddy,
Ummadi Nagarjuna,
Gudi Yamini,
Venkatapuram Padmavathi,
Adivireddy Padmaja
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3012
Subject(s) - chemistry , antimicrobial , diazomethane , bacillus subtilis , aspergillus niger , combinatorial chemistry , organic chemistry , bacteria , biochemistry , genetics , biology
A variety of 3,4‐disubstituted pyrroles and pyrazoles were synthesized by the treatment of 1,3‐dipolar reagents viz., tosylmethyl isocyanide, and diazomethane to heteroaryl chalcones and evaluated for their antimicrobial activity. Among all the tested compounds, 14b and 15b displayed promising antimicrobial activity when compared with the standards particularly against Bacillus subtilis and Aspergillus niger .