New Synthetic Approaches for Cytotoxic Activity of Novel 1,8‐Naphthyridine Derivatives | Zendy

ElHadidy Sherihan A. | Zendy; Selim Yasser A. | Zendy

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New Synthetic Approaches for Cytotoxic Activity of Novel 1,8‐Naphthyridine Derivatives

Author(s) -

ElHadidy Sherihan A.,

Selim Yasser A.

Publication year - 2018

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3011

Subject(s) - chemistry , cytotoxic t cell , reagent , combinatorial chemistry , in vitro , ehrlich ascites carcinoma , cytotoxicity , stereochemistry , organic chemistry , biochemistry

A series of substituted 1,8‐naphthyridine derivatives was synthesized as cytotoxic agent by using starting material 1,4‐dihydro‐4‐oxo‐1,8‐naphthyridine‐3‐carbohydrazide ( 1 ). Further reactions on compound 1 were processed with different reagents to afford the corresponding 3‐heteraryl‐1,8‐naphthyridine derivatives 2–22 . In vitro cytotoxic activities of new synthesized compounds were assayed against Ehrlich ascites carcinoma, which showed that compounds 3 and 12 had the more potent cytotoxic activity.

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