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One‐Pot Synthesis of Hydroxy Pyrazolo[1,2‐ a ][1,2,4]triazoles and Their Dehydration Using Recyclable Ionic Liquids as Reaction Media
Author(s) -
Meena Kalawati,
Khurana Jitender M.,
Malik Amita
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3006
Subject(s) - chemistry , ionic liquid , ethyl acetoacetate , dehydration , condensation , reaction conditions , environmentally friendly , organic chemistry , condensation reaction , one pot synthesis , combinatorial chemistry , catalysis , ecology , biochemistry , physics , biology , thermodynamics
An eco‐friendly, simple, and efficient one‐pot new procedure has been developed for the synthesis of hydroxy phenylhexahydropyrazolo[1,2‐ a ][1,2,4]triazoles by condensation of 4‐phenylurazole, aldehydes, and ethyl/methyl acetoacetate using ionic liquid [bmim]BF 4 in presence of l ‐proline at 80°C. The hydroxy pyrazolo[1,2‐ a ][1,2,4]triazoles could be dehydrated in presence of [bmim]HSO 4 to give corresponding phenyltetrahydropyrazolo[1,2‐ a ][1,2,4]triazoles in high yields. High yields, less reaction time, operational simplicity, and recyclability of reaction media are the advantages of this protocol.