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Curcuminoids in Multi‐Component Synthesis
Author(s) -
Ajavakom Vachiraporn,
Yutthaseri Thatsawan,
Chantanatrakul Rachata,
Suksamrarn Apichart,
Ajavakom Anawat
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3005
Subject(s) - chemistry , curcuminoid , curcumin , component (thermodynamics) , combinatorial chemistry , condensation , organic chemistry , condensation reaction , catalysis , biochemistry , physics , thermodynamics
The introduction of a 1,3‐dicarbonyl unit in curcuminoid derivatives for multi‐component reactions (MCRs) to furnish six‐membered heterocyclic compounds has been reviewed. Attention has focused on the assembly of the three‐component Biginelli reactions relating to curcumin or tetrahydrocurcumin (THC), aromatic aldehydes and urea as substrates. The hybrid molecules of two bioactive agents were designed and synthesized by using these MCRs concepts. The four‐component modified Hantzsch condensation was the latest development of this synthetic route. The possible mechanism of the MCRs of both curcumin and THC were also summarized.