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A novel microwave‐assisted green synthesis of condensed 2‐substituted‐pyrimidin‐4(3 H )‐ones under solvent‐free conditions
Author(s) -
Jain Kishor S.,
Bariwal Jitender B.,
Phoujdar Manisha S.,
Nagras Madhuri A.,
Amrutkar Rakesh D.,
Munde Manoj K.,
Tamboli Riyaj S.,
Khedkar Samrat A.,
Khiste Rahul H.,
Vidyasagar Nikhil C.,
Dabholkar Vinit V.,
Kathiravan M. K.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.30
Subject(s) - chemistry , condensation , benzene , quinazolinone , solvent , catalysis , organic chemistry , microwave , green chemistry , thiophene , lewis acids and bases , combinatorial chemistry , reaction mechanism , quantum mechanics , physics , thermodynamics
A rapid microwave‐assisted green chemical synthesis of condensed 2‐substituted‐pyrimidin‐4(3 H )‐ones 3, 4, and 5 involving the condensation of a variety of nitriles with o ‐aminoesters of thiophene 2a , 2b , 2c , 2d , 2e , benzene 2f , dimethoxybenzene 2g and quinazolinone 2h in the presence of catalytic amount of HCl alone or with the Lewis acid AlCl 3 under solvent‐free conditions, is described for the first time. This novel and clean one‐pot methodology, which is characterized by very short reaction times and easy workup procedures, can be exploited to generate a diverse library of condensed pyrimidine heterocycles. J. Heterocyclic Chem., (2009)