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Synthesis and Antimicrobial Activity of 2‐(4‐(Hydroxyalkyl)‐1 H ‐1,2,3‐triazol‐1‐yl)‐ N ‐substituted propanamides
Author(s) -
Kaushik C.P.,
Luxmi Raj
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2988
Subject(s) - chemistry , antimicrobial , enterobacter aerogenes , aspergillus niger , sodium azide , escherichia coli , candida albicans , amide , click chemistry , staphylococcus aureus , stereochemistry , combinatorial chemistry , organic chemistry , bacteria , microbiology and biotechnology , biochemistry , genetics , biology , gene
A series of 21 2‐(4‐(hydroxyalkyl)‐1 H ‐1,2,3‐triazol‐1‐yl)‐ N ‐substituted propanamides (1,4‐disubstituted 1,2,3‐triazoles having amide linkage and hydroxyl group) have been synthesized from click reaction between terminal alkyne and 2‐azido‐ N ‐substituted propanamide (generated in situ from reaction of 2‐bromo‐ N ‐substituted propanamide and sodium azide) and characterized by FTIR, 1 H NMR, 13 C NMR spectroscopy, and HRMS. All the newly synthesized triazoles were tested in vitro for antimicrobial activity against four bacterial cultures – Escherichia coli , Enterobacter aerogenes , Klebsiella pneumoniae , and Staphylococcus aureus – and two fungal cultures – Candida albicans and Aspergillus niger . The synthesized 1,4‐disubstituted 1,2,3‐triazoles displayed moderate to good antimicrobial potential against the tested strains.