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Microwave‐assisted synthesis and evaluation of antimicrobial activity of 3‐{3‐(s‐aryl and s‐heteroaromatic)acryloyl}‐2 H ‐chromen‐2‐one derivatives
Author(s) -
Ajani Olayinka O.,
Nwinyi Obinna C.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.298
Subject(s) - chemistry , yield (engineering) , antimicrobial , aryl , condensation , combinatorial chemistry , organic chemistry , alkyl , materials science , metallurgy , physics , thermodynamics
The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3‐acetylcoumarin ( 1 ) with aromatic and heteroaromatic aldehydes to afford the corresponding aromatic chalcones ( 2a , 2b , 2c , 2d , 2e , 2f , 2g , 2h , 2i , 2j ) and heteroaromatic chalcones ( 3a , 3b , 3c , 3d , 3e and 4a , 4b , 4c , 4d , 4e ), respectively, in good to excellent yield within 1–3 min. The chemical structures were confirmed by analytical and spectral data. All the synthesized compounds were screened for their antibacterial activity and 3‐{3‐(4‐dimethylaminophenyl)acryloyl}‐2 H ‐chromen‐2‐one ( 2i ) was discovered to be the most active at minimum inhibitory concentration (MIC) value of 7.8 μg/mL. J. Heterocyclic Chem., (2010).