Premium
Synthesis and Evaluation of Novel [1,2,4]Triazolo[1,5‐ c ]quinazoline Derivatives as Antibacterial Agents
Author(s) -
Zeydi Masoud Mohammadi,
Montazeri Naser,
Fouladi Mahdi
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2979
Subject(s) - chemistry , micrococcus luteus , bacillus cereus , hydrazine (antidepressant) , quinazoline , antibacterial activity , bacillus subtilis , escherichia coli , staphylococcus aureus , potassium , aryl , organic chemistry , nuclear chemistry , bacteria , biochemistry , genetics , alkyl , biology , gene
A series of new 2‐aryl‐5‐methyl‐[1,2,4]triazolo[1,5‐ c ]quinazoline derivatives ( 5a – 5g ) have been synthesized by the reaction of 3‐amino‐2‐methylquinazolin‐4‐(3 H )‐one ( 3 ) with aromatic nitriles in potassium tert ‐butoxide under reflux conditions. 3‐Amino‐2‐methylquinazolin‐4‐(3 H )‐one ( 3 ) was synthesized by the reaction 2‐methyl‐4 H ‐benzo[ d ][1,3]oxazin‐4‐one ( 2 ) with hydrazine hydrate. The chemical structure of products was confirmed by IR, 1 H, 13 C NMR and elemental analysis. These compounds were screened for antibacterial [ Staphylococcus aureus (ATCC 25923), Bacillus cereus (ATCC 11778), Micrococcus luteus (ATCC 9341), Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853)] activities, using the zone inhibition method.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom