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Synthesis and Evaluation of Novel [1,2,4]Triazolo[1,5‐ c ]quinazoline Derivatives as Antibacterial Agents
Author(s) -
Zeydi Masoud Mohammadi,
Montazeri Naser,
Fouladi Mahdi
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2979
Subject(s) - chemistry , micrococcus luteus , bacillus cereus , hydrazine (antidepressant) , quinazoline , antibacterial activity , bacillus subtilis , escherichia coli , staphylococcus aureus , potassium , aryl , organic chemistry , nuclear chemistry , bacteria , biochemistry , genetics , alkyl , biology , gene
A series of new 2‐aryl‐5‐methyl‐[1,2,4]triazolo[1,5‐ c ]quinazoline derivatives ( 5a – 5g ) have been synthesized by the reaction of 3‐amino‐2‐methylquinazolin‐4‐(3 H )‐one ( 3 ) with aromatic nitriles in potassium tert ‐butoxide under reflux conditions. 3‐Amino‐2‐methylquinazolin‐4‐(3 H )‐one ( 3 ) was synthesized by the reaction 2‐methyl‐4 H ‐benzo[ d ][1,3]oxazin‐4‐one ( 2 ) with hydrazine hydrate. The chemical structure of products was confirmed by IR, 1 H, 13 C NMR and elemental analysis. These compounds were screened for antibacterial [ Staphylococcus aureus (ATCC 25923), Bacillus cereus (ATCC 11778), Micrococcus luteus (ATCC 9341), Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853)] activities, using the zone inhibition method.