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Design and Synthesis of Some New Quinoxaline‐Based Heterocycles
Author(s) -
El Azab Islam H.,
Elkanzi Nadia A. A.,
Gobouri Adil A.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2978
Subject(s) - quinoxaline , chemistry , azole , combinatorial chemistry , azine , proton nmr , conjugate , stereochemistry , organic chemistry , antifungal , medicine , mathematical analysis , mathematics , dermatology
Considering quinoxaline as a privileged structure for developing probes of impressive therapeutic potentials, some new azole and azine conjugates of quinoxaline were synthesized. Thus, ethyl 3‐amino‐1,4‐dihydroquinoxaline‐2‐carboxylate ( 2 ) was prepared as one‐pot three‐component product and incorporated in a series of manipulations including cyclocondensation reactions to afford a series of pharmacophoric motif conjugates 8–12 , 14, 15–17 , 20–23 , 24–29 , 30 – 37 , and 38–43 in fair yields. The newly synthesized were characterized by IR, 1 H NMR, 13 C NMR, and mass spectral data.