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Synthesis and Antioxidant Activity of a New Class of Pyridinylcarbamoylmethyl Pyrrolyl/Pyrazolylcarboxamides
Author(s) -
Gudi Yamini,
Gundala Sravya,
Venkatapuram Padmavathi,
Adivireddy Padmaja,
Chippada Appa Rao,
Allagadda Rajasekhar
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2973
Subject(s) - chemistry , antioxidant , ascorbic acid , organic chemistry , combinatorial chemistry , food science
A new class of pyridinylcarbamoylmethyl pyrrolyl/pyrazolylcarboxamides was prepared from the synthetic intermediate pyridinylcarbamoylmethyl cinnamamide adopting simple and versatile synthetic methodologies. All the synthesized compounds were evaluated for antioxidant activity. Among all the tested compounds, the methoxy‐substituted pyrazolyl pyridines displayed significant antioxidant activity in all the three methods when compared with the standard ascorbic acid. Moreover, compounds having more number of electron‐donating groups exhibited greater activity.