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Quinolone analogues 10: Synthesis of antimalarial quinolones having pyridyl moiety in N1‐side chain
Author(s) -
Kurasawa Yoshihisa,
Yoshida Kiminari,
Yamazaki Naoki,
Kaji Eisuke,
Sasaki Kenji,
Hiwasa Yoshiko,
Tsukamoto Akiko,
Ito Hideyuki
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.297
Subject(s) - chemistry , quinolone , moiety , carboxylate , stereochemistry , combinatorial chemistry , antimalarial agent , side chain , antibiotics , organic chemistry , malaria , plasmodium falciparum , biochemistry , polymer , immunology , biology
Novel 4‐quinolone‐3‐carboxylates 6,7 and 4‐quinolone‐3‐carboxylic acids 8a , 8b , 9a , 9b , 9c , 10a , 10b , 11a , 11b , 11c were synthesized from 4‐hydroxyquinoline‐3‐carboxylates. Ethyl 1‐[1‐ethoxycarbonyl‐2‐(4‐pyridyl)vinyl]‐6‐fluoro‐4‐oxoquinoline‐3‐carboxylate 7a was found to show antimalarial activity from the screening data. J. Heterocyclic Chem., (2010).