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Synthesis and Insecticidal Activity of Novel Thiazole Acrylonitrile Derivatives
Author(s) -
Cao Shengwen,
Liu Aiping,
Liu Weidong,
Liu Xingping,
Ren Yeguo,
Pei Hui,
Huang Lu,
Zheng Xi,
Huang Mingzhi,
Wu Daoxin
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2961
Subject(s) - acrylonitrile , chemistry , thiazole , aphis , bioassay , potency , elemental analysis , proton nmr , organic chemistry , combinatorial chemistry , botany , biochemistry , in vitro , aphid , genetics , copolymer , biology , polymer
A series of novel thiazole acrylonitrile derivatives was designed and synthesized utilizing NC‐510 as a precursor. Their structures were characterized by NMR spectrometry, MS, and elemental analysis. The results of bioassay indicated that some of these title compounds exhibited 100% mortality at 50 mg/L against Aphis fabae . In particular, the compound 11c displayed the best activity: Its LC 50 value achieved 1.45 mg/L, and its insecticidal potency is comparable with that of NC‐510.