Synthesis and Insecticidal Activity of Novel Thiazole Acrylonitrile Derivatives | Zendy

Cao Shengwen | Zendy; Liu Aiping | Zendy; Liu Weidong | Zendy; Liu Xingping | Zendy; Ren Yeguo | Zendy; Pei Hui | Zendy; Huang Lu | Zendy; Zheng Xi | Zendy; Huang Mingzhi | Zendy; Wu Daoxin | Zendy

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Synthesis and Insecticidal Activity of Novel Thiazole Acrylonitrile Derivatives

Author(s) -

Cao Shengwen,

Liu Aiping,

Liu Weidong,

Liu Xingping,

Ren Yeguo,

Pei Hui,

Huang Lu,

Zheng Xi,

Huang Mingzhi,

Wu Daoxin

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2961

Subject(s) - acrylonitrile , chemistry , thiazole , aphis , bioassay , potency , elemental analysis , proton nmr , organic chemistry , combinatorial chemistry , botany , biochemistry , in vitro , aphid , genetics , copolymer , biology , polymer

A series of novel thiazole acrylonitrile derivatives was designed and synthesized utilizing NC‐510 as a precursor. Their structures were characterized by NMR spectrometry, MS, and elemental analysis. The results of bioassay indicated that some of these title compounds exhibited 100% mortality at 50 mg/L against Aphis fabae . In particular, the compound 11c displayed the best activity: Its LC 50 value achieved 1.45 mg/L, and its insecticidal potency is comparable with that of NC‐510.

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