Premium
Phosphine‐Catalyzed Diastereoselective [3 + 3] Annulation of Morita–Baylis–Hillman Carbonates with C , N ‐Cyclic Azomethine Imines
Author(s) -
Zhang Lei,
Yang Wenjun,
Zhou Leijie,
Liu Honglei,
Huang Jiaxing,
Xiao Yumei,
Guo Hongchao
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2958
Subject(s) - chemistry , annulation , isoquinoline , phosphine , catalysis , medicinal chemistry , organic chemistry , stereochemistry
In this paper, phosphine‐catalyzed [3 + 3] annulation of Morita–Baylis–Hillman carbonates with C , N ‐cyclic azomethine imines has been achieved. The reaction worked smoothly under mild conditions to afford 4,6,7,11b‐tetrahydro‐1 H ‐pyridazino[6,1‐ a ]isoquinoline derivatives in high yields with good to excellent diastereoselectivities.