Phosphine‐Catalyzed Diastereoselective [3 + 3] Annulation of Morita–Baylis–Hillman Carbonates with  C , N ‐Cyclic Azomethine Imines | Zendy

Zhang Lei | Zendy; Yang Wenjun | Zendy; Zhou Leijie | Zendy; Liu Honglei | Zendy; Huang Jiaxing | Zendy; Xiao Yumei | Zendy; Guo Hongchao | Zendy

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Phosphine‐Catalyzed Diastereoselective [3 + 3] Annulation of Morita–Baylis–Hillman Carbonates with C , N ‐Cyclic Azomethine Imines

Author(s) -

Zhang Lei,

Yang Wenjun,

Zhou Leijie,

Liu Honglei,

Huang Jiaxing,

Xiao Yumei,

Guo Hongchao

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2958

Subject(s) - chemistry , annulation , isoquinoline , phosphine , catalysis , medicinal chemistry , organic chemistry , stereochemistry

In this paper, phosphine‐catalyzed [3 + 3] annulation of Morita–Baylis–Hillman carbonates with C , N ‐cyclic azomethine imines has been achieved. The reaction worked smoothly under mild conditions to afford 4,6,7,11b‐tetrahydro‐1 H ‐pyridazino[6,1‐ a ]isoquinoline derivatives in high yields with good to excellent diastereoselectivities.

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