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Synthesis of Indane‐Based 1,5‐Benzothiazepines Derived from 3‐Phenyl‐2,3‐dihydro‐1 H ‐inden‐1‐one and Antimicrobial Studies Thereof
Author(s) -
Mor Satbir,
Nagoria Savita,
Sindhu Suchita,
Khatri Mohini,
Sidhu Gurdeep,
Singh Virender
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2948
Subject(s) - chemistry , aspergillus niger , antimicrobial , bacillus subtilis , candida albicans , staphylococcus epidermidis , naphthalene , ciprofloxacin , minimum inhibitory concentration , indane , corpus albicans , microbiology and biotechnology , bacteria , stereochemistry , staphylococcus aureus , food science , organic chemistry , antibiotics , biochemistry , biology , genetics
In the present study, a series of 20 indane‐based 1,5‐benzothiazepines ( 5a – t ) has been prepared derived from 3‐phenyl‐2,3‐dihydro‐1 H ‐inden‐1‐one ( 1 ). All the synthesized 1,5‐benzothiazepines ( 5a – t ) were screened for their in vitro antimicrobial activities against four bacteria [ Bacillus subtilis (MTCC 441), Staphylococcus epidermidis (MTCC 6880), Escherichia coli (MTCC 1652), and Pseudomonas aeruginosa (MTCC 424)] and two fungi [ Candida albicans (MTCC 227) and Aspergillus niger (MTCC 8189)]. Among all the tested derivatives, 5n and 5o against E. coli displayed more inhibitory activity than that of the reference drug, ciprofloxacin, while the derivatives 5c , 5m – o , 5s , and 5t against C. albicans , and 5d , 5e , 5n , 5o , 5s , and 5t against A. niger were found to be more potent than the standard drug, that is, fluconazole.