Premium
Adaptable Access for Naphthaquinone Annulation: Bioactivity and Molecular Modeling Evaluations
Author(s) -
Hamama Wafaa S.,
Hassanien Alaa ElDin E.,
Zoorob Hanafi H.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2947
Subject(s) - chemistry , lawsone , moiety , annulation , quinazoline , reagent , stereochemistry , combinatorial chemistry , molecule , organic chemistry , catalysis
A series of nitrogenous compounds containing 1,4‐naphhoquinone moiety such as lawsone, benzo[g]quinolone‐5,10‐diones, benzo[g]quinazoline‐5,10‐diones, and benzo[b] naphthodiazepine‐6,11‐diones analogs was synthesized by reaction of Lawsone (1) with different reagents. The structures of produced compounds were confirmed by variable spectra analysis. The molecular structures of the obtained molecules were studied. The products exhibited potent antioxidant and antitumor activities.