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Synthesis of Highly Substituted Pyrrole and Dihydro‐1 H ‐Pyrrole Containing Barbituric Acids via Catalyst‐Free One‐Pot Four‐Component Reactions
Author(s) -
Ghandi Mehdi,
Jourablou Ali,
Abbasi Alireza
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2924
Subject(s) - chemistry , barbituric acid , phenylglyoxal , pyrrole , catalysis , organic chemistry , component (thermodynamics) , reaction conditions , combinatorial chemistry , medicinal chemistry , amino acid , biochemistry , physics , arginine , thermodynamics
A new one‐pot, four‐component reaction of phenylglyoxal or ethylglyoxalate, 1,3‐dicarbonyls, N , N‐ dimethylbarbituric acid, and aromatic amines for the synthesis of highly substituted pyrroles or dihydro‐1 H ‐pyrrole containing barbituric acid in moderate‐to‐good yields is described. Short reaction time, mild reaction condition, use of simple experimental procedure, and prompt isolation of the products are some advantages of this protocol.