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Synthesis, Cell Viability, and Flow Cytometric Fluorescence Pulse Width Analysis of Dendrimers with Indazoles Surface Unit
Author(s) -
Jayanthi Mani,
Rajakumar Perumal
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2913
Subject(s) - chemistry , dendrimer , flow cytometry , viability assay , cell , fluorescence , mtt assay , indazole , cell growth , biophysics , microbiology and biotechnology , biochemistry , stereochemistry , physics , biology , quantum mechanics
Dendrimers with indazole surface units were synthesized up to second generation in good yields, and the MTT cell proliferation assay was carried out with A549 lung adenocarcinoma cell lines. The cell viability and the flow cytometry analysis shows that increased mitochondrial activity was concomitant with increased mitochondrial biomass with no loss of mitochondrial membrane potential or cell death.