A Convenient Regioselective Synthesis of Novel 1,4‐Phenylenemethylene‐6,6′‐ bis ‐([1,2,4‐triazolo]‐[4,3‐ b ][1,2,4]‐triazin‐7(1 H )‐ones) | Zendy

Hassaneen Hamdi M. | Zendy; Saleh Fatma M. | Zendy; Mohammed Yasmin Sh. | Zendy; Awad Enas M. | Zendy

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A Convenient Regioselective Synthesis of Novel 1,4‐Phenylenemethylene‐6,6′‐ bis ‐([1,2,4‐triazolo]‐[4,3‐ b ][1,2,4]‐triazin‐7(1 H )‐ones)

Author(s) -

Hassaneen Hamdi M.,

Saleh Fatma M.,

Mohammed Yasmin Sh.,

Awad Enas M.

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2910

Subject(s) - chemistry , oxazolone , potassium hydroxide , regioselectivity , halide , medicinal chemistry , antimicrobial , potassium , combinatorial chemistry , organic chemistry , catalysis

The target compounds 6,6′‐(1,4‐phenylenedimethylene)‐bis(3‐thioxo‐1,2,4‐triazin‐5(1 H )‐one) 4,5 were prepared from reaction of oxazolone 1 with thiosemicarbazide and 4‐phenylthiosemicarbazide, in potassium hydroxide solution, respectively. Reaction of 4 with hydrazonoyl halides 6 afforded triazolotriazine derivatives 7 . Also, 5 reacted with 6 to give the corresponding substitution products 8 . Antimicrobial and antitumor activities for some compounds were studied.

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