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A Convenient Regioselective Synthesis of Novel 1,4‐Phenylenemethylene‐6,6′‐ bis ‐([1,2,4‐triazolo]‐[4,3‐ b ][1,2,4]‐triazin‐7(1 H )‐ones)
Author(s) -
Hassaneen Hamdi M.,
Saleh Fatma M.,
Mohammed Yasmin Sh.,
Awad Enas M.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2910
Subject(s) - chemistry , oxazolone , potassium hydroxide , regioselectivity , halide , medicinal chemistry , antimicrobial , potassium , combinatorial chemistry , organic chemistry , catalysis
The target compounds 6,6′‐(1,4‐phenylenedimethylene)‐bis(3‐thioxo‐1,2,4‐triazin‐5(1 H )‐one) 4,5 were prepared from reaction of oxazolone 1 with thiosemicarbazide and 4‐phenylthiosemicarbazide, in potassium hydroxide solution, respectively. Reaction of 4 with hydrazonoyl halides 6 afforded triazolotriazine derivatives 7 . Also, 5 reacted with 6 to give the corresponding substitution products 8 . Antimicrobial and antitumor activities for some compounds were studied.