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Synthesis and biological activity of novel 1,3,5‐trisubstituted 1,2,4‐triazole derivatives
Author(s) -
Parmar Kokila,
Suthar Bharat,
Prajapati Saraju,
Suthar Arun
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.291
Subject(s) - chemistry , antifungal , indoline , triazole , combinatorial chemistry , 1,2,4 triazole , in vitro , antibacterial activity , stereochemistry , organic chemistry , biochemistry , bacteria , dermatology , biology , genetics , medicine
Triazole skeleton is ubiquitous in pharmaceutically important compounds. A novel series of indoline‐containing triazole with different amides are described, which exhibit antibacterial and antifungal activities. The chemical synthesis strategies used, the complete characterization of the compounds, their in vitro screening, and the promising activity as reflected in the MIC values are reported. J. Heterocyclic Chem., (2010).