Premium
One‐Pot Three‐Component Synthesis of 6 H ‐chromeno[4,3‐ b ] or Cyclopenta[ b ]furo[3,2‐ f ]quinoline Derivatives
Author(s) -
Li Zhe,
Li XiaoJing,
Liu JianQuan,
Wang XiangShan
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2904
Subject(s) - chemistry , quinoline , component (thermodynamics) , cyclopentane , carboxylate , catalysis , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , thermodynamics , physics
Two series of furo[3,2‐ f ]quinoline‐2‐carboxylate were obtained via a three‐component reaction of aldehydes, 5‐aminobenzofuran‐2‐carboxylate, and 4‐hydroxy‐2 H ‐chromen‐2‐one or cyclopentane‐1,3‐dione in DMF under catalyst‐free condition in high yields. This one‐pot three‐component reaction provided an efficient method for the synthesis of fused polycyclic heterocycles for bioactive screening.