Synthesis of new 4‐oxo‐thiazolidine‐5‐ylidenes of antitumor and antioxidant activities | Zendy

Aly Ashraf A. | Zendy; Brown Alan B. | Zendy; AbdelAziz Mohamed | Zendy; AbuoRahma Gamal ElDin A. A. | Zendy; Radwan Mohamed F. | Zendy; Ramadan Mohamed | Zendy; GamalEldeen Amira M. | Zendy

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Synthesis of new 4‐oxo‐thiazolidine‐5‐ylidenes of antitumor and antioxidant activities

Author(s) -

Aly Ashraf A.,

Brown Alan B.,

AbdelAziz Mohamed,

AbuoRahma Gamal ElDin A. A.,

Radwan Mohamed F.,

Ramadan Mohamed,

GamalEldeen Amira M.

Publication year - 2010

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.290

Subject(s) - chemistry , thiazolidine , hydrazine (antidepressant) , antioxidant , ethanol , organic chemistry , medicinal chemistry , combinatorial chemistry , biochemistry

Reaction of diacyl thiocarbohydrazides with dimethyl but‐2‐ynedioate in refluxing ethanol led to 4‐oxa‐thiazolidine‐5‐ylidene‐acetates in good yields. Reaction of the newly prepared N ‐(2‐(propan‐2‐ylidene) hydrazine‐carbonothioyl)arylhydrazides with dimethyl but‐2‐ynedioate gave the corresponding ( Z )‐methyl‐2‐arylhydrazide‐4‐oxo‐3‐(propan‐2‐ylideneamino)thiazolidine‐5‐ylidene)‐acetates. The mechanism is discussed. Antitumor and antioxidant activities have been also investigated. J. Heterocyclic Chem., (2010).

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