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Synthesis of new 4‐oxo‐thiazolidine‐5‐ylidenes of antitumor and antioxidant activities
Author(s) -
Aly Ashraf A.,
Brown Alan B.,
AbdelAziz Mohamed,
AbuoRahma Gamal ElDin A. A.,
Radwan Mohamed F.,
Ramadan Mohamed,
GamalEldeen Amira M.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.290
Subject(s) - chemistry , thiazolidine , hydrazine (antidepressant) , antioxidant , ethanol , organic chemistry , medicinal chemistry , combinatorial chemistry , biochemistry
AbstractReaction of diacyl thiocarbohydrazides with dimethyl but‐2‐ynedioate in refluxing ethanol led to 4‐oxa‐thiazolidine‐5‐ylidene‐acetates in good yields. Reaction of the newly prepared N ‐(2‐(propan‐2‐ylidene) hydrazine‐carbonothioyl)arylhydrazides with dimethyl but‐2‐ynedioate gave the corresponding ( Z )‐methyl‐2‐arylhydrazide‐4‐oxo‐3‐(propan‐2‐ylideneamino)thiazolidine‐5‐ylidene)‐acetates. The mechanism is discussed. Antitumor and antioxidant activities have been also investigated. J. Heterocyclic Chem., (2010).