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Pyrazolo[5,1‐ c ][1,2,4]triazoles: Antimicrobial, Antitumor Activities, and Computational Docking Studies
Author(s) -
Farghaly Thoraya A.,
Abdallah Magda A.,
Mahmoud Huda K.,
ElMetwaly Nashwa,
Elaasser Mahmoud
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2892
Subject(s) - chemistry , autodock , antimicrobial , docking (animal) , triethylamine , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , medicine , nursing , in silico , gene
A new series of pyrazolotriazoles 7a–l , 11 , and 15a–c derived from the reaction of 3‐amino‐4‐(arylhydrazono)‐4,5‐dihydropyrazol‐5‐one 3a , b with various types of hydrazonoyl chlorides 4 , 10 , 12 , and 13 was being synthesized in existence of triethylamine. The spectral data were assured the postulated structures for all compounds. All 7‐arylazopyrazolo[5,1‐ c ][1,2,4]triazole derivatives 7a–l , 11 , and 15a–c have been evaluated for their antimicrobial and antitumor activities, and the results show that some derivatives have good to mild utility as antitumor and antibacterial operators. Moreover, the computational studies using AutoDock tools 4.2 are confirming the results in biological activity.