Premium
Facile One‐pot, Three‐component Synthesis of Novel Bis‐heterocycles Incorporating 5 H ‐chromeno[2,3‐ b ]pyridine‐3‐carbonitrile Derivatives
Author(s) -
Abdelmoniem Amr M.,
Ghozlan Said A. S.,
Abdelmoniem Doaa M.,
Elwahy Ahmed H. M.,
Abdelhamid Ismail A.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2890
Subject(s) - chemistry , malononitrile , dimedone , pyridine , piperidine , aldehyde , component (thermodynamics) , medicinal chemistry , organic chemistry , catalysis , combinatorial chemistry , physics , thermodynamics
Novel bis‐chromeno[2,3‐ b ]pyridine derivatives were synthesized with good yields by a clean and efficient methodologies involving one‐pot three‐component synthesis of bis‐aldehydes, malononitrile dimer, and dimedone in the presence of piperidine as a catalyst in EtOH. Depending on the length and position of the spacer in the bis‐aldehyde derivatives 1 , the reactions proceeded to give either the bis(2,4‐diamino‐tetrahydro‐5 H ‐chromeno[2,3‐ b ]pyridine‐3‐carbonitriles) 4 or bis(4‐amino‐2,6‐dioxo‐hexahydro‐2 H ‐chromeno[2,3‐ b ]pyridine‐3‐carbonitriles) 5 . All of the new compounds have been characterized by spectral data.