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2‐(3,4‐Dichlorophenylimino)‐5‐((3‐( p ‐substitutedphenyl)‐1‐phenyl‐1 H ‐pyrazol‐4‐yl)methylene)thiazolidin‐4‐one as an Antibacterial, Antifungal and Antimycobacterial Agent
Author(s) -
Brahmbhatt Harshad,
Bhatt Anjani K.,
Das Arun K.,
Paul Parimal,
Sharma Sangita
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2889
Subject(s) - antimycobacterial , chemistry , candida albicans , aspergillus niger , staphylococcus aureus , methylene , pseudomonas aeruginosa , antibacterial activity , mycobacterium tuberculosis , microbiology and biotechnology , stereochemistry , bacteria , organic chemistry , tuberculosis , biochemistry , biology , medicine , genetics , pathology
2‐(3,4‐Dichlorophenylimino)‐5‐((3‐( p ‐substitutedphenyl)‐1‐phenyl‐1 H ‐pyrazol‐4‐yl)methylene) thiazolidin‐4‐one has been selected as a target bio‐active molecules. Newly synthesized compounds were screened with Eschericha coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442) for antibacterial, Candida albicans (MTCC 227), Aspergillus niger (MTCC 282), Aspergillus clavatus (MTCC 1323) for antifungal activity and H 37 Rv for antimycobacterial activity. Compounds 3a , 3c , 3d , 3e , and 3h are potentially active against Staphylococcus aureus , while 3h is active against C. albicans . Compounds 3d and 3f are active against H 37 Rv for mycobacterium tuberculosis. Other possesses moderate to good activity. The structures of synthesized compounds were firmly established by well‐defined elemental analyses (C, H, N, S/O) and spectral analysis technique likes, IR, 1 H NMR and GC–MS.