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Synthesis of Some 4‐Quinolinyl Pyridines and their Antimicrobial and Docking Studies
Author(s) -
Kumar Ramesh,
Khanna Radhika,
Kumar Parvin,
Kumar Vikas,
Kamboj Ramesh C.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2876
Subject(s) - chemistry , dhps , antimicrobial , docking (animal) , dna gyrase , escherichia coli , yield (engineering) , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , medicine , plasmodium falciparum , materials science , nursing , malaria , gene , metallurgy , immunology , biology
A series of some substituted diethyl 4‐(2‐chloroquinolin‐3‐yl)‐2,6‐dimethylpyridine‐3,5‐dicarboxylates has been synthesized from substituted diethyl4‐(2‐chloroquinolin‐3‐yl)‐1,4‐dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates (1,4‐DHPs) by treating the latter with SiO 2 –HNO 3 which proved to be a better oxidant in terms of product yield, reaction time, and cost. Further, these compounds were screened for their antimicrobial activity. All the diethyl 4‐(2‐chloroquinolin‐3‐yl)‐2,6‐dimethylpyridine‐3,5‐dicarboxylates exhibited more potent activities than the corresponding 1,4‐DHPs. Further, docking simulation of the most active and least active compounds 3e and 2e into Escherichia coli topoisomerase II DNA Gyrase B was also performed.