Premium
Benzenesulfonic Acid: A Versatile Catalyst for the Synthesis of Bis(indolyl)methanes as Antioxidants
Author(s) -
Simha Pulla Reddy,
Mangali Madhu Sekhar,
Kuppireddy Gari Divya,
Venkatapuram Padmavathi,
Adivireddy Padmaja
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2873
Subject(s) - benzenesulfonic acid , chemistry , sonication , catalysis , yield (engineering) , antioxidant , acetonitrile , organic chemistry , chromatography , materials science , metallurgy
The reaction of indoles with carbonyl compounds in the presence of 5 mol% benzenesulfonic acid in acetonitrile was performed to synthesize bis(indolyl)methane derivatives adopting conventional and ultrasonication methodologies. The reaction proceeded in shorter reaction time in ultrasonication methodology leading to high yield of the products. All the synthesized compounds were tested for antioxidant activity. Among all the tested compounds, 3k exhibited pronounced antioxidant activity.