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Study on a New Method for Synthesis of Mirabegron
Author(s) -
Xu Guiqing,
Mao Shen,
Mao Longfei,
Jiang Yuqin,
Zhou Yong,
Shen Jiaxuan,
Dong Wenpei
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2871
Subject(s) - mirabegron , chemistry , yield (engineering) , aniline , overactive bladder , organic chemistry , medicine , materials science , metallurgy , alternative medicine , pathology
Mirabegron is a muscle relaxing drug for the treatment of overactive bladder. The existing synthetic methods for mirabegron produced intermediate product 4‐(2‐(phenethylamino)ethyl)aniline, which complicated the final product purification process. In this study, we designed a new synthetic route for mirabegron with low cost starting materials and a production of mirabegron at a 99.6% purity and a 61% overall yield. Particularly, this new synthetic route did not produce side product 4‐(2‐(phenethylamino)ethyl)aniline, which significantly simplified the product purification process.