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Synthesis and Biological Activity of Amide Compounds Containing Pyrazole Mandelic Acid Groups
Author(s) -
Xie Yan,
Ruan XiangHui,
Gong HuaYu,
Wang YiHui,
Wang XiaoBin,
Zhang JuPing,
Li Qin,
Xue Wei
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2862
Subject(s) - chemistry , mandelic acid , tobacco mosaic virus , amide , pyrazole , bioassay , biological activity , organic chemistry , combinatorial chemistry , stereochemistry , virus , biochemistry , in vitro , virology , genetics , biology
A series of novel mandelic acid pyrazole amide compounds were synthesized and characterized. Moreover, their antiviral activities against tobacco mosaic virus were evaluated. The bioassay results indicated that as‐prepared compounds showed antiviral activity against tobacco mosaic virus at a concentration of 500 g/mL. The curative activity of compound 4g is 59.5%, which was comparable with positive control ( Ningnanmycin, 61.0%). The inactivation activity of the compound 4l exhibited 80.1%, which was higher than that of Ningnanmycin (75.0%), and its protective activity was 88.7%, which is comparable with that of Ningnanmycin (90.7%).