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TiO 2 –SiO 2 Catalyzed Eco‐friendly Synthesis and Antioxidant Activity of Benzopyrano[2,3‐ d ]pyrimidine Derivatives
Author(s) -
Kabeer Shaik Ahammed,
Reddy Gajjala Raghavendra,
Sreelakshmi Poola,
Manidhar Darla Mark,
Reddy Cirandur Suresh
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2856
Subject(s) - chemistry , malononitrile , environmentally friendly , catalysis , pyrimidine , antioxidant , reusability , organic chemistry , ring (chemistry) , stereochemistry , ecology , software , computer science , biology , programming language
A cost‐effective and eco‐friendly synthesis of benzopyrano[2,3‐ d ]pyrimidine derivatives has been developed via three component one‐pot tandem approach by condensing different salicylaldehydes and secondary amines with malononitrile in the presence of TiO 2 –SiO 2 catalyst at 80°C under solvent‐free conditions. Mild experimental conditions, reusability of the catalyst, and cost effectiveness are the merits of this procedure. Compounds 4g , 4h , and 4i bearing 2‐OMe group on the hydroxyphenyl group linked to the central carbon present in between the two nitrogen atoms of the pyrimidine ring were found to exhibit good antioxidant activity while other compounds have moderate antioxidant activity.